Characterizing the role of IL-33/ST2 axis in regulating anti-tumor function by CD8 T cells during tumor metastasis in the omentum.

Abstract The omentum, a visceral adipose tissue, is frequent site of metastasis for gastric and ovarian cancers. Advanced cancer almost always metastasizes to the omentum. Currently available therapies do not control tumor growth long-term there recurrence metastasis. In mice, cells injected intraperitoneally implant in omentum grow progressively despite tumor-specific CD8 T cells. lack effective immunity due part, rapid Treg recruitment which provides an immunosuppressive environment support growth. Tregs are specialized population called tissue associated (VAT-Tregs). A portion omental VAT-associated express ST2, receptor Interleukin-33 (IL-33), suggesting that local IL-33 production may contribute Treg-mediated suppression We also detected persistent, continuously expanding, Given can enhance effector function by promote their persistence presence chronic antigen stimulation, we investigating how regulates balance immune-suppression CD8-mediated cell killing context tissue. R01CA216234